<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE book PUBLIC "-//NLM//DTD BITS Book Interchange DTD v2.3 20210610//EN" "BITS-book2.3.dtd"> <book xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" book-type="conference-proceedings" dtd-version="2.3" xml:lang="ru"> <front> <book-meta>  <book-id book-id-type="isbn">978-5-6040397-1-7</book-id>   <book-id pub-id-type="doi">10.21661/a-444</book-id>   <title-group>  <book-title xml:lang="ru">Актуальные направления научных исследований: перспективы развития</book-title>   </title-group>  <description xml:lang="ru"> <p>В сборнике представлены материалы участников IV Международной научно–практической конференции, посвященные актуальным направлениям развития образования и науки. Приведены результаты теоретических и прикладных изысканий представителей научного и образовательного сообщества в данной области.
Предназначен для широкого круга читателей.</p> </description>   <contrib-group>  <contrib contrib-type="editor" id="editor1">  <contrib-id contrib-id-type="role">chief_editor</contrib-id>    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Широков</surname> <given-names>Олег Николаевич</given-names> </name>   </name-alternatives>   <email xlink:type="simple">425954@rambler.ru</email> </contrib>  <contrib contrib-type="editor" id="editor2">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Абрамова</surname> <given-names>Людмила Алексеевна</given-names> </name>   </name-alternatives>   <email xlink:type="simple">labramova@interactive-plus.ru</email> </contrib>  <contrib contrib-type="editor" id="editor3">  <contrib-id contrib-id-type="role">executive_editor</contrib-id>    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Яковлева</surname> <given-names>Татьяна Валериановна</given-names> </name>   </name-alternatives>   <email xlink:type="simple">info@interactive-plus.ru</email> </contrib>  <contrib contrib-type="editor" id="editor4">  <contrib-id contrib-id-type="role">associate_editor</contrib-id>    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Петрова</surname> <given-names>Марина Геннадьевна</given-names> </name>   </name-alternatives>   <email xlink:type="simple">mpetrova@interactive-plus.ru</email> </contrib>  </contrib-group>   <contrib-group>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm1">  <contrib-id contrib-id-type="role">chief_editor</contrib-id>    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Широков</surname> <given-names>Олег Николаевич</given-names> </name>   </name-alternatives>   </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm2">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Абрамова</surname> <given-names>Людмила Алексеевна</given-names> </name>   </name-alternatives>   </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm3">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Бекназаров</surname> <given-names>Рахым Агибаевич</given-names> </name>   </name-alternatives>   </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm4">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Иваницкий</surname> <given-names>Александр Юрьевич</given-names> </name>   </name-alternatives>   </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm5">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Стойчева</surname> <given-names>Мария Стойчева</given-names> </name>   </name-alternatives>   </contrib>  </contrib-group>   <event>  <event-desc xml:lang="ru">Актуальные направления научных исследований: перспективы развития</event-desc>   <event-desc xml:lang="en">Relevant lines of scientific research: theory and practice</event-desc>   <conf-date> <day>01</day> <month>01</month> <year>1900</year> </conf-date>    <conf-loc xml:lang="ru">Чебоксары</conf-loc>  </event>   <publisher> <publisher-name>Центр научного сотрудничества «Интерактив плюс»</publisher-name> </publisher>    <pub-date pub-type="collection"> <year>2018</year> </pub-date>   <volume>1</volume>   <permissions> <copyright-statement>Copyright &#x00A9; Мусатов М. И., 2017</copyright-statement> <copyright-year>2017</copyright-year> <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"> <license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p> </license> </permissions>  </book-meta> <book-part book-part-type="conference-paper"> <book-part-meta>   <book-id custom-type="publisher-id" pub-id-type="custom">466993</book-id> <title-group>  <chapter-title xml:lang="ru">Куркума в химиотерапии мышиной меланомы</chapter-title>   </title-group>  <contrib-group>   <contrib contrib-type="author" id="author1"> <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9692-9700</contrib-id>  <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Мусатов</surname> <given-names>Михаил Иванович</given-names> </name>    </name-alternatives>  <email xlink:type="simple">lugamus@yandex.ru</email> <xref ref-type="aff" rid="aff1"/> </contrib>   <aff-alternatives id="aff1">   <aff xml:lang="ru">  <institution>ФГБНУ «НИИ фундаментальной и клинической иммунологии»</institution>   <country>Россия</country> </aff>     </aff-alternatives>  </contrib-group>   <fpage>111</fpage> <lpage>115</lpage>   <abstract xml:lang="ru"> <p>в эксперименте на мышах-самках CBF1 исследовалось влияние масляного экстракта куркумы (С. Longa, МЭК), добавлявшегося в корм животных, на рост меланомы В16 и продолжительность жизни животных по сравнению с лечением доксорубицином (ДР). Показано, что МЭК на 25-й день эксперимента снижает объем опухолей на 53%, ДР – на 74%, но МЭК вызывает увеличение продолжительности жизни животных на 14% больше, чем ДР.</p> </abstract>           <kwd-group xml:lang="ru">  <kwd>доксорубицин</kwd>  <kwd>мыши</kwd>  <kwd>куркума</kwd>  <kwd>Curcuma longa</kwd>  <kwd>меланома В16</kwd>  </kwd-group>        </book-part-meta> </book-part> </front>  <back> <ref-list> <title>References</title>  <ref id="ref1"> <label>1</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Ganapathi R. Modulation in vitro and in vivo of Cytotoxicity but not Cellular Levels of Doxorubicin by the Calmodulin Inhibitor Trifluoperazine is Dependent on the Level of Resistance / R. Ganapathi, H. Schmidt, D. Grabowski, M. Melia, N. Ratliff // Br. J. 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