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Lots of pyogenic and destructive processes of abdominal cavity and retroperitoneal space lead to the development of multiple organ failure and syndrome of endogenous intoxication. One of the basic aims of pharmacology is to search for the new immunomodulatory substances such as cytokine – Roncoleukin. This substance efficiency was evaluated by observing a study group and comparing it with a control one. As a result, the study group showed immunological status improvement, and laboratory parameters improvement correlated with clinical presentation ones.