List of publications on a keyword: «биодоступность»

The rectal way can be used to produce both local and systemic effect. When rectally administered medications are entered through nijneangarsk of the mucous membrane of the rectum, where the rectal venous (internal hemorrhoidal) plexus. The bioavailability with this route of administration is quite high, due to the abundant blood supply of the rectum, structure of the veins of this region, the so-called glomeruli or cavernous bodies, position them around the diameter, the presence of anastomoses between the cavernous bodies, the outflow of venous blood bypassing the liver that increases the rate of achievement of maximum concentration of LP in the blood. The advantages of this method are: the rapid development of therapeutic effect (5-15 min), high rate of absorption of LV, comparable to intramuscular way of introduction, the absence of irritating action of medicinal substances on the gastric mucosa, the possibility of application in psychiatric practice, patients in an unconscious state, in Pediatrics and geriatrics. The limited introduction of drugs with a complex structure, due to the lack of enzymes in the rectum, the small size of the suction surface and the short contact time of the drug with the mucosa are the main disadvantages of this method.