List of publications on a keyword: «рецепторы»

В ходе анализа научной литературы и патентной документации РФ выявлено наличие значительного количества исследований, посвященных терапии ожогов ротовой полости и профилактическим процедурам, проводимыми после получения химической травмы. Учитывая высокую болезненность в послеожоговых состояниях полости рта, а также значительное снижение качества жизни пациентов в этот период, по-прежнему, актуальной остается проблема создания комплексного лекарственного средства, способствующего ускорению восстановления вкусовых рецепторов клеток непарного выроста дна ротовой полости, обладающего ранозаживляющим, противовоспалительным, антимикробным и обезболивающим действием.

В статье проведен анализ современного состояния проблемы патогенеза рака эндометрия. Авторы делают вывод, что вопросы патогенеза рака эндометрия обсуждаются во взаимосвязи с метаболическим синдромом, однако молекулярные механизмы развития этой патологии не изучены.

According to the authors among the new psychoactive substances, the number of which is growing every year, despite the measures aimed at the obstacles to their dissemination there discovered the most frequent violations of psychotic conditions associated with use of synthetic cannabinoid in clinical practice. On the black market, they are distributed through online shops, under the guise of herbal mixtures for Smoking. When ingested, this group of drugs at the peak of intoxication raises a number of mental (different according to the depth of impaired consciousness, auditory and visual hallucinations, panic attacks, acute psychotic paranoid disorders, catatonic stupor, polar affective disorders, acute polythematic delusional symptoms) and somatic disorders (disorders of heart rhythm and conduction, acute ischemic disorders, hypertension, depression of respiratory activity, violation of thermoregulation, development of acute renal failure, vomiting, expressed cephalgia, clinic of hypokalemia). In the reviewed literature and authors own observations there have been discovered some cases of mental addiction development to synthetic cannabinoids. The analysis of new literature data and own clinical observations helped the authors to compare the psychotropic effects caused by this group of drugs, relative to other known surfactants. The toxic effects of CSC on the body greatly exceeds the use of plant cannabinoids, and it has almost the same effects as the synthetic cathinone’s. The speed of formation of psychological dependence is lower compared to synthetic cathinone. Developing current strategies for diagnosis, treatment, and rehabilitation of patients who use synthetic cannabinoids remains an important task for practical healthcare.

The majority of synthetic cannabinoids (SC), belongs to the group of so-called designer drugs distributed through illegal online shopping. The first reports of this group of psychoactive substances appeared in the 70s of the last century. Today, according to various estimates, there are over 160 varieties of synthetic cannabinoids, and this figure is increasing annually due to the synthesis of new substances in the group. This group of substances is designed to «copy» the psychoactive effects of cannabis. Initially, these substances were created solely for research purposes, to study the endocannabinoid system of the person. Natural THC is a partial agonist of cannabinoid receptors. Synthetic cannabinoids are full agonists CB1R and CB2R types of cannabinoid receptors. Most countries in the world, including Russia, at the legislative level have taken restrictive measures for preventing the spread of this group of substances. In order to circumvent the legislative measures, the producers of synthetic cannabinoids regularly changing the chemical formula. Each year, an increasing number of emergency hospital admissions associated with the use of synthetic cannabinoids in the peer-reviewed literature describes the deaths directly attributable to medical complications after taking synthetic cannabinoids. Numerous studies have proven the possibility of developing psychological dependence due to the use of synthetic cannabinoids. The proposed review of the literature is presented for the purpose of organizing data in the field of synthetic cannabinoids.

The paper presents the results of an investigation of ESR-dependent RBC adrenoreactivity (RBC-AR) among young males and females. It has been revealed that young females’ predominant RBC-AR type is the aggregant type, manifested in ESR increase in the presence of adrenaline (in vitro). Young males’ most common type is the areactive type, which reflects, obviously, more stable physical and psycho-emotional state.

В статье рассматриваются вопросы организации полисенсорной насыщенной среды и специальных занятий по развитию сенсорной интеграции на базе КОГОАУ «Лицей естественных наук», выделяются положительные результаты использования сенсорной комнаты как прекрасного профилактического средства борьбы со школьным переутомлением.